Sodium and Potassium Currents Influence Wallerian Degeneration of Injured Drosophila Axons
نویسندگان
چکیده
منابع مشابه
Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.
Axons degenerate after injury and in neuropathies and disease via a self-destruction program whose mechanism is poorly understood. Axons that have lost connection to their cell bodies have altered electrical and synaptic activities, but whether such changes play a role in the axonal degeneration process is not clear. We have used a Drosophila model to study the Wallerian degeneration of motoneu...
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Axon degeneration during development is required to sculpt a functional nervous system and is also a hallmark of pathological insult, such as injury [1, 2]. Despite similar morphological characteristics, very little overlap in molecular mechanisms has been reported between pathological and developmental degeneration [3-5]. In the peripheral nervous system (PNS), developmental axon pruning relie...
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All analysis of the sodium and potassium conductances of Myxicola giant axons was made in terms of the Hodgkin-Huxley m, n, and h variables. The potassium conductance is proportional to n(2). In the presence of conditioning hyperpolarization, the delayed current translates to the right along the time axis. When this effect was about saturated, the potassium conductance was proportional to n(3)....
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The scnsitivity of sodium cfltux to the removal of potassium ions from the cxtcrnal solution and the change in sodium cffiux occurring when sodium ions arc also removed were obscrvcd to be rclated. When Tris was used to replace cxtcrnal sodium ions, increases in sodium effiux were always observed whether the sensitivity of sodium cfflux to external potassium ions was weak or strong. Greater per...
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The sensitivity of sodium efflux to the removal of potassium ions from the external solution and the change in sodium efflux occurring when sodium ions are also removed were observed to be related. When Tris was used to replace external sodium ions, increases in sodium efflux were always observed whether the sensitivity of sodium efflux to external potassium ions was weak or strong. Greater per...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1007-13.2013